Department of Translational Research
2025年1月30日掲載
Research Focus
Director,Takayuki Takimoto
▪Unraveling the pathophysiological mechanisms of idiopathic PPFE, with a focus on architectural distortion, dysphagia-related complications, thoracic kinematics, and respiratory physiology.
▪Exploring the pathophysiology of pulmonary diseases associated with lymphangitic abnormalities, such as lymphangiomatosis and yellow nail syndrome.
Current Research Projects
Principal Investigator: NHO Network Study “Dysphagia and Dysphonia in Interstitial Lung Disease – A Multicenter Prospective Observational Study (R6-EBM (Respiratory)-01)”
Principal Investigator: “Retrospective Study on Thoracic Kinematic Abnormalities in Interstitial Pneumonia”
Principal Investigator: “Investigation of Vascular Endothelial Growth Factors in Pulmonary Diseases with Lymphatic Abnormalities”
Principal Investigator: “Retrospective Study on Thoracic Kinematic Abnormalities in Interstitial Pneumonia”
Principal Investigator: “Investigation of Vascular Endothelial Growth Factors in Pulmonary Diseases with Lymphatic Abnormalities”
Research Grants Awarded
2016–2018 JSPS Grant-in-Aid for Scientific Research (C) KAKENHI
Elucidation of the Role of Tetraspanins and Vesicular Transport in Tumor Progression of Lymphangioleiomyomatosis
2017 Osaka Community Foundation, Fund for Intractable Diseases Grant
Development of Novel Therapeutic Strategies for Lymphangioleiomyomatosis
2019–2021 JSPS Grant-in-Aid for Scientific Research (C) KAKENHI
Comprehensive Approach Targeting Extracellular Vesicles for Biomarker Discovery in Lymphangioleiomyomatosis
2022–2024 JSPS Grant-in-Aid for Scientific Research (C) KAKENHI
Proteomics-Based Biomarker Exploration for Pulmonary Amyloidosis
Elucidation of the Role of Tetraspanins and Vesicular Transport in Tumor Progression of Lymphangioleiomyomatosis
2017 Osaka Community Foundation, Fund for Intractable Diseases Grant
Development of Novel Therapeutic Strategies for Lymphangioleiomyomatosis
2019–2021 JSPS Grant-in-Aid for Scientific Research (C) KAKENHI
Comprehensive Approach Targeting Extracellular Vesicles for Biomarker Discovery in Lymphangioleiomyomatosis
2022–2024 JSPS Grant-in-Aid for Scientific Research (C) KAKENHI
Proteomics-Based Biomarker Exploration for Pulmonary Amyloidosis
Intellectual Property
Patent Application Number: JP 2018-048266 Title: Biomarker for Lymphangioleiomyomatosis
Publications
1. Takimoto T, Sumikawa H, Inoue Y, Arai T. Auto-Fluorescence Imaging of Bronchoscopy in Mounier-Kuhn Syndrome: Negative Auto-Fluorescence Sign. Am J Respir Crit Care Med. 2024 Apr 17. Epub ahead of print.
2. Takimoto T, Takeuchi N, Inoue Y, Arai T. Vocal cord palsy in interstitial lung disease: Involvement of architectural distortion by pleuroparenchymal fibroelastosis. Pulmonology. 2024 Jan 31:S2531-0437(24)00001-1.
3. Isobe K, Nakamura Y, Sakamoto S, Tomii K, Takimoto T, Miyazaki Y, Matsumoto M, Sugino K, Ichikado K, Moriguchi S, Yamaguchi K, Baba T, Ozasa H, Igata F, Anabuki K, Homma S, Date H, Suda T, Kishi K. Immune checkpoint inhibitors in patients with lung cancer having chronic interstitial pneumonia. ERJ Open Res. 2024 Mar 4;10(2):00981-2023.
4. Takimoto T, Yanagisawa A, Arai T, Inoue Y. Vocal cord paralysis associated with pleuroparenchymal fibroelastosis: A case report and literature review. Respir Investig. 2023 Sep;61(5):548-552.
5. Takimoto T, Sumikawa H, Arai T, Inoue Y, et al. Left vocal cord paralysis in idiopathic pleuroparenchymal fibroelastosis: A case report. JMA J. 2023 Apr 14;6(2);220-222.
6. Takimoto T, Kobayashi T, Minomo S. Concomitant Recurrent Pneumothorax and Takotsubo Cardiomyopathy in a Chronic Obstructive Pulmonary Disease Patient. Cureus. 2022 Oct 29;14(10):e30850.
7. Takimoto T. Corticosteroids for pulmonary lymphangitic carcinomatosis. BMJ Support Palliat Care. 2022 Oct 27:bmjspcare-2022-003983.
8. Takimoto T, Nakamura Y. Serum Biomarkers in a Radiological Pattern of Non-Fibrotic Hypersensitivity Pneumonitis: Implications for Mechanistic Difference and Differential Diagnosis. Diseases. 2022 Jun 27;10(3):36.
9. Takimoto T. Post-capillary pulmonary hypertension in patients with interstitial lung disease: An important but overlooked phenomenon. Respiratory investigation. 2022 Jan;60(1);180-181.
10. Azuma K, Takimoto T, Kasai T, Hirose M, Hatsuda K, Sugimoto C, Arai T, Akira M, Inoue Y. Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis. Respiratory investigation. 2021 May 6;S2212-5345(21)00073-3.
11. Enomoto T, Takimoto T, Kagawa T, Tachibana K, Sugimoto C, Arai T, Sakurai T, Kasai T, Akira M, Hayashi S, Inoue Y. Histologically Proven Dendriform Pulmonary Ossification: A Five-case Series. Internal medicine (Tokyo, Japan). 2021 Feb 01.
12. Takimoto T, Kitaoka H, Kijima T. What Is Tracheobronchomalacia in Obstructive Lung Disease? Chest. 2021 Jan;159(1):442-443.
13. Nakamura Y, Takimoto T, Kobayashi T, Tachibana K, Kasai T, Akira M, Arai T, Inoue Y. Drug-related pneumonitis with radiographic hypersensitivity pneumonitis pattern: Three case series. Respir Med Case Rep. 2021;34;101498.
14. Adachi Y, Takimoto T, Takeda M, Matsumoto K, Takeuchi N, Kagawa T, Sakamoto T, Kasai T, Sugimoto C, Inoue Y, Tachibana K, Arai T, Inoue Y. Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case. Respir Med Case Rep. 2020 Dec 1;31:101313.
15. Takimoto T. Micronodular Pattern of Organizing Pneumonia or Hypersensitivity Pneumonia Induced by an Immune Checkpoint Inhibitor? American journal of respiratory and critical care medicine. 2020 11 15;202(10);1485-1486.
16. Takimoto T, Kagawa T, Tachibana K, Arai T, Inoue Y. Massive atelectasis by mucoid impaction in an asthma patient during treatment with anti-interleukin-5 receptor antibody. Respirol Case Rep. 2020 Jun 18;8(6):e00599.
17. Takimoto T, Minomo S, Azuma K, Tsuyuguchi K, Suzuki K. A rare cause of pneumatosis intestinalis: Intestinal amyloidosis reactive to pulmonary Mycobacterium avium infection. Int J Infect Dis. 2020 Aug;97:329-330
2. Takimoto T, Takeuchi N, Inoue Y, Arai T. Vocal cord palsy in interstitial lung disease: Involvement of architectural distortion by pleuroparenchymal fibroelastosis. Pulmonology. 2024 Jan 31:S2531-0437(24)00001-1.
3. Isobe K, Nakamura Y, Sakamoto S, Tomii K, Takimoto T, Miyazaki Y, Matsumoto M, Sugino K, Ichikado K, Moriguchi S, Yamaguchi K, Baba T, Ozasa H, Igata F, Anabuki K, Homma S, Date H, Suda T, Kishi K. Immune checkpoint inhibitors in patients with lung cancer having chronic interstitial pneumonia. ERJ Open Res. 2024 Mar 4;10(2):00981-2023.
4. Takimoto T, Yanagisawa A, Arai T, Inoue Y. Vocal cord paralysis associated with pleuroparenchymal fibroelastosis: A case report and literature review. Respir Investig. 2023 Sep;61(5):548-552.
5. Takimoto T, Sumikawa H, Arai T, Inoue Y, et al. Left vocal cord paralysis in idiopathic pleuroparenchymal fibroelastosis: A case report. JMA J. 2023 Apr 14;6(2);220-222.
6. Takimoto T, Kobayashi T, Minomo S. Concomitant Recurrent Pneumothorax and Takotsubo Cardiomyopathy in a Chronic Obstructive Pulmonary Disease Patient. Cureus. 2022 Oct 29;14(10):e30850.
7. Takimoto T. Corticosteroids for pulmonary lymphangitic carcinomatosis. BMJ Support Palliat Care. 2022 Oct 27:bmjspcare-2022-003983.
8. Takimoto T, Nakamura Y. Serum Biomarkers in a Radiological Pattern of Non-Fibrotic Hypersensitivity Pneumonitis: Implications for Mechanistic Difference and Differential Diagnosis. Diseases. 2022 Jun 27;10(3):36.
9. Takimoto T. Post-capillary pulmonary hypertension in patients with interstitial lung disease: An important but overlooked phenomenon. Respiratory investigation. 2022 Jan;60(1);180-181.
10. Azuma K, Takimoto T, Kasai T, Hirose M, Hatsuda K, Sugimoto C, Arai T, Akira M, Inoue Y. Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis. Respiratory investigation. 2021 May 6;S2212-5345(21)00073-3.
11. Enomoto T, Takimoto T, Kagawa T, Tachibana K, Sugimoto C, Arai T, Sakurai T, Kasai T, Akira M, Hayashi S, Inoue Y. Histologically Proven Dendriform Pulmonary Ossification: A Five-case Series. Internal medicine (Tokyo, Japan). 2021 Feb 01.
12. Takimoto T, Kitaoka H, Kijima T. What Is Tracheobronchomalacia in Obstructive Lung Disease? Chest. 2021 Jan;159(1):442-443.
13. Nakamura Y, Takimoto T, Kobayashi T, Tachibana K, Kasai T, Akira M, Arai T, Inoue Y. Drug-related pneumonitis with radiographic hypersensitivity pneumonitis pattern: Three case series. Respir Med Case Rep. 2021;34;101498.
14. Adachi Y, Takimoto T, Takeda M, Matsumoto K, Takeuchi N, Kagawa T, Sakamoto T, Kasai T, Sugimoto C, Inoue Y, Tachibana K, Arai T, Inoue Y. Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case. Respir Med Case Rep. 2020 Dec 1;31:101313.
15. Takimoto T. Micronodular Pattern of Organizing Pneumonia or Hypersensitivity Pneumonia Induced by an Immune Checkpoint Inhibitor? American journal of respiratory and critical care medicine. 2020 11 15;202(10);1485-1486.
16. Takimoto T, Kagawa T, Tachibana K, Arai T, Inoue Y. Massive atelectasis by mucoid impaction in an asthma patient during treatment with anti-interleukin-5 receptor antibody. Respirol Case Rep. 2020 Jun 18;8(6):e00599.
17. Takimoto T, Minomo S, Azuma K, Tsuyuguchi K, Suzuki K. A rare cause of pneumatosis intestinalis: Intestinal amyloidosis reactive to pulmonary Mycobacterium avium infection. Int J Infect Dis. 2020 Aug;97:329-330