Department of Intractable Lung Diseases

Rare lung disease, including lymphangioleiomyomatosis, pulmonary alveolar proteinosis, idiopathic PPFE (IPPFE), pulmonary ossification, and amyloidosis.

Novel Biomarkers for lymphangioleiomyomatosis and LAM
Pathophysiology of IPPFE
(Effects of the airway deviation on the recurrent nerve, swallowing dysfunction, respiration physiology, etc.)
Pathophysiology of diseases with lymphatic vessel dysfunction (lymphangiomatosis, yellow nail syndrome, etc)
Drug-related pneumonitis

1. Takimoto T, Yanagisawa A, Arai T, Inoue Y. Vocal cord paralysis associated with pleuroparenchymal fibroelastosis: A case report and literature review. Respir Investig. 2023 Sep;61(5):548-552.
2. Takimoto T, Sumikawa H, Arai T, Inoue Y, et al. Left vocal cord paralysis in idiopathic pleuroparenchymal fibroelastosis: A case report. JMA J. 2023 Apr 14;6(2);220-222. 
3. Takimoto T, Nakamura Y. Serum Biomarkers in a Radiological Pattern of Non-Fibrotic Hypersensitivity Pneumonitis: Implications for Mechanistic Difference and Differential Diagnosis. Diseases. 2022 Jun 27;10(3):36.
4. Azuma K, Takimoto T, Kasai T, Hirose M, Hatsuda K, Sugimoto C, Arai T, Akira M, Inoue Y. Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis. Respiratory investigation. 2021 May 6;S2212-5345(21)00073-3.
5. Enomoto T, Takimoto T, Kagawa T, Tachibana K, Sugimoto C, Arai T, Sakurai T, Kasai T, Akira M, Hayashi S, Inoue Y. Histologically Proven Dendriform Pulmonary Ossification: A Five-case Series. Internal medicine (Tokyo, Japan). 2021 Feb 01.
6. Nakamura Y, Takimoto T, Kobayashi T, Tachibana K, Kasai T, Akira M, Arai T, Inoue Y. Drug-related pneumonitis with radiographic hypersensitivity pneumonitis pattern: Three case series. Respir Med Case Rep. 2021;34;101498.
7. Adachi Y, Takimoto T, Takeda M, Matsumoto K, Takeuchi N, Kagawa T, Sakamoto T, Kasai T, Sugimoto C, Inoue Y, Tachibana K, Arai T, Inoue Y. Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case. Respir Med Case Rep. 2020 Dec 1;31:101313. 
8. Takimoto T, Kagawa T, Tachibana K, Arai T, Inoue Y. Massive atelectasis by mucoid impaction in an asthma patient during treatment with anti-interleukin-5 receptor antibody. Respirol Case Rep. 2020 Jun 18;8(6):e00599. 
9. Takimoto T, Minomo S, Azuma K, Tsuyuguchi K, Suzuki K. A rare cause of pneumatosis intestinalis: Intestinal amyloidosis reactive to pulmonary Mycobacterium avium infection. Int J Infect Dis. 2020 Aug;97:329-330