心身医学・緩和医療研究室

室長：所　昭宏
副室長：松田　能宣

心身医学、緩和医療、精神腫瘍学に関する多数の臨床研究を行っています。当院は呼吸器の専門施設であることから、呼吸困難、非がん呼吸器疾患の緩和ケアに関する研究テーマを多く扱っています。患者さんの全人的な苦痛軽減につながるエビデンスを創出することを目指しています。

非がん性呼吸器疾患患者の呼吸困難に対するオピオイド全身投与の有効性・安全性に関する多施設レジストリ研究
 
間質性肺疾患の呼吸困難に対するモルヒネの有効性に関する
ランダム化プラセボ対照第II相試験
 
がん患者の片側胸水に伴う呼吸困難に対する体位交換の有効性に関する
ランダム化クロスオーバー比較試験

2025年

• Miwa S, Mori M, Imai K, Ikari T, Watanabe H, Matsumoto Y, Matsuda Y, Aiki S, Yamaguchi T. Clinical Characteristics and Treatment Outcomes of Terminal Dyspnea: A Multicenter Cohort Study. J Palliat Med. 2025 Dec 12.
• Hasegawa T, Mori M, Yamaguchi T, Imai K, Matsuda Y, Maeda I, Hatano Y, Ishiki H, Otani H; East Asian collaborative cross-cultural study to elucidate the drying process (EASED) investigators. Pharmacological Strategies for Pain Relief in Patients with Terminal Delirium: A Secondary Data Analysis. Palliat Med Rep. 2025 Oct 24;6(1):527-532.
• Mori M, Yamaguchi T, Suzuki K, Matsuda Y, Matsunuma R, Watanabe H, Ikari T, Matsumoto Y, Imai K, Yokomichi N, Miwa S, Yamauchi T, Okamoto S, Inoue S, Inoue A, Hui D, Morita T, Satomi E. Effectiveness of Opioid Titration for Terminal Dyspnea in Opioid-Naïve and -Tolerant Patients with Advanced Cancer: A Multicenter Prospective Cohort Study. J Palliat Med. 2025 Nov 21.
• Arai T, Hirose M, Kagawa T, Takeuchi N, Kobayashi T, Inoue Y, Matsuda Y. Effectiveness of a 5-Hydroxytryptamine Type 3 Receptor Antagonist for Treating Nintedanib-Induced Diarrhea: A Prospective Observational Study. J Clin Med. 2025 Nov 7;14(22):7914.
• Kuze Y, Matsuda Y, Yanagisawa A, Kanaoka K, Sugimoto H, Kurahara Y, Kagawa T, Takimoto T, Arai T, Inoue Y, Tokoro A. Delirium in terminally ill patients with interstitial lung diseases: a retrospective study. Ann Palliat Med. 2025 Sep;14(5):447-455.
• Arakawa S, Amano K, Koshimoto S, Okamura S, Sakaguchi T, Matsuda Y, Tokoro A, Takeuchi T, Mori N, Satomi E. Assessing the need for multimodal care in anorexia and cachexia patients with advanced cancer referred to palliative care: a secondary analysis of a multicenter survey in Japan. Support Care Cancer. 2025 Sep 6;33(10):837.
• Hasegawa T, Mori M, Yamaguchi T, Imai K, Matsuda Y, Maeda I, Hatano Y, Ishiki H, Otani H. Longitudinal changes in delirium motor subtypes among patients with advanced cancer in inpatient hospice and palliative care units: A secondary analysis of a multicenter cohort study. Support Care Cancer. 2025 Aug 16;33(9):791.
• Yamanaka K, Hasegawa T, Matsuda Y, Inoue S, Tanimukai H, Wada S, Kako J; Japan Psycho-Oncology Society/the Japanese Association of Supportive Care in Cancer’s Clinical Practice Guidelines for Delirium in Cancer Patients Group. Opioid switching to improve delirium symptoms in patients with cancer: a systematic review. Int J Clin Oncol. 2025 Oct;30(10):1896-1905.
• Sumitani H, Tamiya A, Iwahashi Y, Sekinada D, Tsukaguchi A, Tanaka Y, Iguchi T, Inagaki Y, Taniguchi Y, Kagawa T, Matsuda Y, Okishio K. Case of a rare EGFR mutation L747P identified using the lung cancer compact Panel™ leading to successful Afatinib treatment. Respir Med Case Rep. 2025 Jul 5;57:102255.
• Suzuki K, Matsuda Y, Mori M, Tasaki J, Matsunuma R, Ikari T, Miwa S, Aiki S, Takagi Y, Kiuchi D, Oyamada S, Ariyoshi K, Kihara K, Yamaguchi T. The Effectiveness of Regular Opioids for Dyspnea Among Opioid-Tolerant Patients with Cancer: A Comparison of Increasing Baseline Opioids Versus Opioid Switch/Combination Therapy. J Palliat Med. 2025 Jul;28(7):924-930.
• Matsuda Y, Mori M, Tokoro A, Taniguchi Y, Aiki S, Takagi Y, Kiuchi D, Suzuki K, Ito M, Oyamada S, Ariyoshi K, Yamaguchi T. Minimal Clinically Important Difference in the Integrated Palliative Care Outcome Scale for Cancer Dyspnea. J Pain Symptom Manage. 2025 Oct;70(4):335-340.
• Kanno Y, Nakano K, Kajiwara K, Kobayashi M, Morikawa M, Matsuda Y, Shimizu Y, Niino M, Suzuki M, Shimazu T, Kako J. Nursing Support for Nonpharmacological Interventions to Prevent Delirium in Patients with Cancer: A Scoping Review. J Palliat Med. 2025 May 26.
• Kobayashi M, Kajiwara K, Nakano K, Kanno Y, Morikawa M, Matsuda Y, Kako J. Nursing Supports for Managing Nausea and Vomiting in Patients with Cancer Having a Prognosis of Months or Weeks: A Multisite Cross-Sectional Study of Palliative Care Nurses in Japan. Palliat Med Rep. 2025 Feb 10;6(1):71-75.
• Taniguchi Y, Tamiya A, Kamiyama Y, Sumitani H, Iwahashi Y, Tsukaguchi A, Sugimoto E, Inagaki Y, Nakao K, Matsuda Y, Takeda M, Kasai T, Okishio K, Shimizu S. Real-world Data of the Lung Cancer Compact Panel™ in Non-small Cell Lung Cancer Using Tissue Samples. Anticancer Res. 2025 Apr;45(4):1607-1615.
• Kako J, Kajiwara K, Kobayashi M, Ito Y, Ichikura K, Matsuda Y, Yamaguchi T. Exploring Psychotherapy Approaches for Dyspnea: A Systematic Review Protocol. Palliat Med Rep. 2025 Feb 21;6(1):84-89.
• Nakano K, Kanno Y, Kajiwara K, Kobayashi M, Morikawa M, Matsuda Y, Kako J. Nursing Support for Constipation in Palliative Care Units in Japan: A Multisite Cross-Sectional Study. Palliat Med Rep. 2025 Jan 8;6(1):1-5.
• Hasegawa T, Mori M, Yamaguchi T, Imai K, Matsuda Y, Maeda I, Hatano Y, Yokomichi N, Hamano J, Morita T; East Asian Collaborative Cross‐Cultural Study to Elucidate the Dying Process (EASED) investigators. Pharmacological Strategies for Providing Patients With Delirium Relief From Terminal Dyspnea: A Secondary Data Analysis. Cancer Med. 2025 Feb;14(3):e70677.
• Kanno Y, Nakano K, Kajiwara K, Kobayashi M, Morikawa M, Matsuda Y, Kako J. Nursing Practices for Preventing Delirium in Patients with Cancer with Prognoses of Months and Weeks: A Multi-Site Cross-Sectional Study in Japan. Am J Hosp Palliat Care. 2025 Nov;42(11):1169-1180.
• Hasegawa T, Mori M, Yamaguchi T, Imai K, Matsuda Y, Maeda I, Hatano Y, Yokomichi N, Hamano J, Morita T; East Asian Collaborative Cross-Cultural Study to Elucidate the Dying Process (EASED) Investigators. Delirium Motor Subtypes and Severity of Physical Symptoms in Patients with Advanced Cancer in Inpatient Hospice/Palliative Care Units: A Multicenter Prospective Cohort Study. J Palliat Med. 2025 Apr;28(4):437-445.
• Koyauchi T, Fujisawa T, Miyashita M, Mori M, Morita T, Yazawa S, Akiyama N, Hagimoto S, Matsuda Y, Tachikawa R, Yasui H, Suzuki M, Asai Y, Ono M, Kimura Y, Ohkouchi S, Tanino Y, Sugino K, Tateishi T, Kato M, Miyamoto A, Saito Y, Sakamoto S, Kono M, Yokomura K, Imokawa S, Sakamoto K, Waseda Y, Handa T, Hattori N, Anabuki K, Yatera K, Shundo Y, Hoshino T, Sakamoto N, Kondoh Y, Tomioka H, Tomii K, Inoue Y, Suda T. Prognostic Awareness and Knowledge of Acute Exacerbation in Patients Dying with Interstitial Lung Disease: A Nationwide Survey. Ann Am Thorac Soc. 2025 Mar;22(3):395-402.
• Hasuo H, Ishiki H, Matsuda Y, Matsuoka H, Kosugi K, Xing M, Akiyama Y, Matsumoto Y, Ishikawa H. Trigger point injections for myofascial pain in terminal cancer: a randomized trial. Pain Med. 2025 Jan 1;26(1):14-21.
• Nakano K, Kanno Y, Kajiwara K, Kobayashi M, Morikawa M, Matsuda Y, Shimizu Y, Shimazu T, Kako J. Nursing Support for Constipation in Patients with Cancer: A Scoping Review. J Palliat Med. 2025 Jan;28(1):115-122.

2024年

• Amano K, Koshimoto S, Okamura S, Sakaguchi T, Arakawa S, Matsuda Y, Tokoro A, Takeuchi T, Satomi E, Wada T, Wada M, Yamada T, Mori N. Association of Systemic Inflammation with Dietary Intake, Nutrition Impact Symptoms, and Eating-Related Distress Among Patients with Advanced Cancer. Healthcare (Basel). 2024 Dec 16;12(24):2533.
• Kajiwara K, Kobayashi M, Nakano K, Kanno Y, Morikawa M, Matsuda Y, Kako J. Use of Nursing Support Among Nurses for Caregiver Burden in Family Caregivers of Terminally Ill Patients with Cancer in Palliative Care Units in Japan: Multisite Cross-Sectional Study. Palliat Med Rep. 2024 Oct 3;5(1):425-429.
• Kako J, Morikawa M, Kajiwara K, Kobayashi M, Kanno Y, Nakano K, Matsuda Y. Nursing Practices for Dyspnea Management in Patients with Cancer Based on Monthly and Weekly Prognoses: A Multi-Site Cross-Sectional Study of Palliative Care Nurses in Japan. Palliat Med Rep. 2024 Oct 14;5(1):440-444.
• Tsukaguchi A, Tamiya A, Fukuda S, Iwahashi Y, Kanaoka K, Tanaka Y, Inagaki Y, Taniguchi Y, Nakao K, Kagawa T, Matsuda Y, Okishio K. Safety and Efficacy of Durvalumab After Chemoradiotherapy in Antinuclear Antibody-positive Patients With Non-small Cell Lung Cancer. Anticancer Res. 2024 Oct;44(10):4517-4524.
• Kako J, Kobayashi M, Matsuda Y, Inoue S, Tanimukai H, Wada S, Hasegawa T. Nonpharmacological Intervention for Delirium in Patients With Cancer: A Scoping Review. J Pain Symptom Manage. 2024 Nov;68(5):e411-e415.
• Yamaguchi T, Matsuda Y, Watanabe H, Kako J, Kasahara Y, Goya S, Kohara H, Mori M, Nakayama T; Japanese Society for Palliative Medicine (JSPM). Treatment Recommendation for Dyspnea in Patients with Advanced Disease: Revised Clinical Guidelines from the Japanese Society for Palliative Medicine. J Palliat Med. 2024 Oct;27(10):1404-1414.
• Shimizu M, Maeda I, Kessoku T, Ishiki H, Matsuura T, Hiratsuka Y, Matsuda Y, Hasegawa T, Imai K, Oyamada S, Satomi E; Phase-R OIC Study Group. The safety and effectiveness of naldemedine for opioid-induced constipation in patients with advanced cancer in real-world palliative care settings: a multicenter prospective observational study. Support Care Cancer. 2024 Jul 10;32(8):504.
• Amano K, Okamura S, Matsuda Y, Baracos VE, Mori N, Miura T, Tatara R, Kessoku T, Tagami K, Otani H, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Morita T, Miyashita M. Associations of nutrition impact symptoms with depression in patients with advanced cancer. Support Care Cancer. 2024 Jun 19;32(7):445.
• Hasegawa T, Okuyama T, Uemura T, Matsuda Y, Otani H, Shimizu J, Horio Y, Watanabe N, Yamaguchi T, Fukuda S, Oguri T, Maeno K, Inagaki Y, Nosaki K, Fukumitsu K, Akechi T. Unrealistic expectations and disclosure of incurability in patients with non-small cell lung cancer. Support Care Cancer. 2024 Jun 10;32(7):421.
• Matsuda Y, Hasuo H, Narita K, Matsuoka H, Morita R, Kiuchi D, Ikari T, Hori T, Okazaki K, Sakai K, Aiki S, Okabayashi H, Oyamada S, Ariyoshi K, Tokoro A, Fukunaga M. Relationship between dyspnoea and related factors in patients with cancer: a cross-sectional study. BMJ Support Palliat Care. 2024 Jan 8;13(e3):e1126-e1132.
• Amano K, Baracos VE, Mori N, Okamura S, Yamada T, Miura T, Tatara R, Kessoku T, Matsuda Y, Tagami K, Otani H, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Morita T, Miyashita M. Associations of nutrition impact symptoms with dietary intake and eating-related distress in patients with advanced cancer. Clin Nutr ESPEN. 2024 Apr;60:313-319.
• Kajiwara K, Kobayashi M, Morikawa M, Kanno Y, Nakano K, Matsuda Y, Shimizu Y, Shimazu T, Kako J. Nursing Support for Caregiver Burden in Family Caregivers of Patients With Cancer: A Scoping Review. Am J Hosp Palliat Care. 2024 Oct;41(10):1184-1194.
• Hasegawa T, Okuyama T, Uemura T, Matsuda Y, Otani H, Shimizu J, Horio Y, Watanabe N, Yamaguchi T, Fukuda S, Oguri T, Maeno K, Taniguchi Y, Nosaki K, Fukumitsu K, Akechi T. Elements of End-of-Life Discussions Associated With Patients' Reported Outcomes and Actual End-of-Life Care in Patients With Pretreated Lung Cancer. Oncologist. 2024 Feb 2;29(2):e282-e289.
• Kobayashi T, Tsuyuguchi K, Shimatani Y, Matsuda Y, Kagawa T, Takimoto T, Takeuchi N, Arai T, Inoue Y. Utility of a loop-mediated isothermal amplification detection kit to diagnose chronic pulmonary aspergillosis. J Infect Chemother. 2024 Jan;30(1):7-11.

2023年

• Morikawa M, Kajiwara K, Kobayashi M, Yusuke K, Nakano K, Matsuda Y, Shimizu Y, Shimazu T, Kako J. Nursing Support for Pain in Patients With Cancer: A Scoping Review. Cureus. 2023 Nov 30;15(11):e49692.
• Kobayashi M, Kajiwara K, Morikawa M, Kanno Y, Nakano K, Matsuda Y, Shimizu Y, Shimazu T, Kako J. Nursing Support for Nausea and Vomiting in Patients With Cancer: A Scoping Review. Cureus. 2023 Nov 3;15(11):e48212.
• Tamiya A, Kanaoka K, Inagaki Y, Taniguchi Y, Nakao K, Matsuda Y, Okishio K, Takeda M, Kasai T, Shigeki S. Enhancing tumour content and tumour cell count using microdissection contributes to higher detection rate of genetic mutations by next-generation sequencers. Heliyon. 2023 Nov 7;9(11):e22082.
• Kako J, Morikawa M, Kobayashi M, Kanno Y, Kajiwara K, Nakano K, Matsuda Y, Shimizu Y, Hori M, Niino M, Suzuki M, Shimazu T. Nursing support for breathlessness in patients with cancer: a scoping review. BMJ Open. 2023 Oct 12;13(10):e075024.
• Kanaoka K, Sumikawa H, Oyamada S, Tamiya A, Inagaki Y, Taniguchi Y, Nakao K, Matsuda Y, Okishio K. Osteoblastic bone reaction in non-small cell lung cancer harboring epidermal growth factor receptor mutation treated with osimertinib. BMC Cancer. 2023 Sep 6;23(1):834.
• Arai T, Kurahara Y, Moda M, Kobayashi T, Matsuda Y, Kagawa T, Sugawara R, Tsuyuguchi K, Inoue Y. COVID-19 in Patients with Pre-Existing Interstitial Lung Disease: Potential Value of a Steroid-Based Treatment Strategy. J Clin Med. 2023 Jul 27;12(15):4940.
• Sadahiro R, Hatta K, Yamaguchi T, Masanori E, Matsuda Y, Ogawa A, Iwata Y, Tokoro A, Nakahara R, Hirayama T, Yanai Y, Ogawa Y, Kayano A, Ariyoshi K, Oyamada S, Uchitomi Y, Akechi T, Yamamoto N, Okita N, Yorikane E, Shimada K, Furukawa T, Hashimoto H, Maeda M, Sato T, Sekimoto A, Sasaki C, Saito E, Uezono Y, Matsuoka H. A multi-centre, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of ramelteon for the prevention of postoperative delirium in elderly cancer patients: a study protocol for JORTC-PON2/J-SUPPORT2103/NCCH2103. Jpn J Clin Oncol. 2023 Aug 30;53(9):851-857.
• Takagi Y, Sato J, Yamamoto Y, Matsunuma R, Watanabe H, Mori M, Hasegawa T, Matsuda Y, Kako J, Kasahara Y, Goya S, Kohara H, Nakayama T, Yamaguchi T. Opioids for the management of dyspnea in cancer patients: a systematic review and meta-analysis. Int J Clin Oncol. 2023 Aug;28(8):999-1010.
• Kanaoka K, Tamiya A, Inagaki Y, Taniguchi Y, Nakao K, Takeda M, Matsuda Y, Okishio K, Shimizu S. Possible False Results With cobas® EGFR Mutation Test v2 and Oncomine Dx Target Test for EGFR Mutation. Anticancer Res. 2023 Jun;43(6):2771-2776.
• Matsuda Y, Tanimukai H, Inoue S, Hirayama T, Kanno Y, Kitaura Y, Inada S, Sugano K, Yoshimura M, Harashima S, Wada S, Hasegawa T, Okamoto Y, Dotani C, Takeuchi M, Kako J, Sadahiro R, Kishi Y, Uchida M, Ogawa A, Inagaki M, Okuyama T. A revision of JPOS/JASCC clinical guidelines for delirium in adult cancer patients: a summary of recommendation statements. Jpn J Clin Oncol. 2023 Aug 30;53(9):808-822.
• Hasegawa T, Ochi T, Goya S, Matsuda Y, Kako J, Watanabe H, Kasahara Y, Kohara H, Mori M, Nakayama T, Yamaguchi T. Efficacy of supplemental oxygen for dyspnea relief in patients with advanced progressive illness: A systematic review and meta-analysis. Respir Investig. 2023 Jul;61(4):418-437.
• Mori M, Yamaguchi T, Suzuki K, Matsuda Y, Matsunuma R, Watanabe H, Ikari T, Matsumoto Y, Imai K, Yokomichi N, Miwa S, Yamauchi T, Okamoto S, Inoue S, Inoue A, Hui D, Morita T, Satomi E; Japanese Dyspnea Relief Investigators. Do Types of Opioids Matter for Terminal Cancer Dyspnea? A Preliminary Multicenter Cohort Study. J Pain Symptom Manage. 2023 Aug;66(2):e177-e184.
• Kanaoka K, Fukuda S, Inagaki Y, Taniguchi Y, Nakao K, Tamiya A, Matsuda Y, Okishio K. Right-sided vocal cord paralysis following stereotactic body radiation therapy for non-small-cell lung cancer: A case report. Thorac Cancer. 2023 Jun;14(16):1534-1537.
• Mori M, Miwa S, Ikari T, Kako J, Hasegawa T, Matsunuma R, Suzuki K, Matsuda Y, Watanabe H, Morita T, Yamaguchi T. Current Management Options for Dyspnea in Cancer Patients. Curr Treat Options Oncol. 2023 Jun;24(6):565-579.
• Fujisawa T, Akiyama N, Morita T, Koyauchi T, Matsuda Y, Mori M, Miyashita M, Tachikawa R, Tomii K, Tomioka H, Hagimoto S, Kondoh Y, Inoue Y, Suda T. Palliative care for interstitial lung disease: A nationwide survey of pulmonary specialists. Respirology. 2023 Jul;28(7):659-668.
• Taniguchi Y, Tamiya A, Yanagisawa A, Shimaya M, Kawakami M, Inagaki Y, Saijo N, Matsuda Y, Okishio K. Cerebral infarction after treatment with dabrafenib plus trametinib for BRAF-V600E-positive non-small cell lung cancer: A case report. Thorac Cancer. 2023 May;14(13):1201-1203.
• Tamiya A, Tamiya M, Inagaki Y, Taniguchi Y, Nakao K, Matsuda Y, Kawamura T, Kunimasa K, Inoue T, Nishino K, Okishio K. Bevacizumab Plus Carboplatin Plus Nab-paclitaxel for Non-squamous Non-small Cell Lung Cancer in a Real-world Setting. Anticancer Res. 2023 Mar;43(3):1325-1330.
• Tanizaki S, Matsumoto K, Tamiya A, Taniguchi Y, Matsuda Y, Uchida J, Ueno K, Kawachi H, Tamiya M, Yanase T, Suzuki H, Okishio K. Sequencing strategies with ramucirumab and docetaxel following prior treatments for advanced non-small cell lung cancer: a multicenter retrospective cohort study. Eur J Clin Pharmacol. 2023 Apr;79(4):503-511.
• Hiroyuki Otani, Amano K, Morita T, Miura T, Mori N, Tatara R, Kessoku T, Matsuda Y, Tagami K, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Shirado AN, Yokomichi N, Miyashita M. Impact of taste/smell disturbances on dietary intakes and cachexia-related quality of life in patients with advanced cancer. Support Care Cancer. 2023 Jan 30;31(2):141.
• Imai K, Morita T, Mori M, Kiuchi D, Yokomichi N, Miwa S, Okamoto S, Yamauchi T, Naito AS, Matsuda Y, Maeda I, Sugano K, Ikenaga M, Inoue S, Satomi E. Visualizing How to Use Antipsychotics for Agitated Delirium in the Last Days of Life. J Pain Symptom Manage. 2023 Jun;65(6):479-489.
• Abe A, Fujisawa D, Miyajima K, Takeuchi E, Takeuchi M, Mimura M, Imai K, Uemura K, Watanabe H, Matsuo N, Matsuda Y, Maeda I, Ogawa A, Yoshiuchi K, Iwase S. Influence of dosing pattern of antipsychotics on treatment outcome of delirium in patients with advanced cancer. Jpn J Clin Oncol. 2023 Mar 30;53(4):321-326.
• Yamaguchi T, Matsunuma R, Matsuda Y, Tasaki J, Ikari T, Miwa S, Aiki S, Takagi Y, Kiuchi D, Suzuki K, Oyamada S, Ariyoshi K, Kihara K, Mori M. Systemic Opioids for Dyspnea in Cancer Patients: A Real-world Observational Study. J Pain Symptom Manage. 2023 May;65(5):400-408.
• Yasuda S, Sugano K, Matsuda Y, Kako J, Takagi Y, Watanabe H, Kasahara Y, Goya S, Kohara H, Mori M, Nakayama T, Yamaguchi T. Systematic review and meta- analysis of the efficacy of benzodiazepines for dyspnea in patients with cancer. Jpn J Clin Oncol. 2023 Mar 30;53(4):327-334.